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Pearl had foot surgery in September, 1998, to repair a hammertoe condition resulting from neuroma surgery on the toe three months earlier. Betadine was liberally applied to her foot and ankle for the surgery. Within several days a thick layer of skin sloughed off just where the betadine had been applied. Since she had been allergic to iodine we weren’t sufficiently concerned to investigate the condition. We also were fooled by the successful use of betadine in the earlier toe surgery. In retrospect it was another indicator of potentially insufficient cortisol being produced and of a lurking immune system problem.